From the BBC:
Ismail Jan died in an air strike in the eastern province of Paktia on Wednesday, the alliance said.
BBC correspondents say he is a leading commander in the Haqqani network, which is linked to the Taliban and al-Qaeda.
Nato and Afghan intelligence believe Haqqani members helped mount the hotel attack, which left 22 people dead.
The bombing of the heavily fortified hotel was an embarrassment to Afghan security forces and may have been an inside job.